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The primary health care of 70-80% of the world's
population is based on the use of medicinal plants derived from
traditional systems of medicine and local health practices. Besides
developing countries and under-developed countries, even western
countries are changing over to alternative medicines due to the more
holistic approach and with substantially fewer side effects - as
opposed to a depleted immune system due to the prolonged use of
allopathic medicine. Immunomodulation or prophylaxis, besides
curative effects in chronic ailments, are also major considerations
in accepting herbal medicines. With an increasing global demand for
herbal medicines, it is necessary that the quality and the
consistency of these drugs is maintained for their maximal efficacy.
Purity and potency of these herbal medicines is only possible under
Good Manufacturing Practice (GMP), quality control and
standardisation of the ingredients/ raw drugs - as well as finished
products. The Laboratory for Medicinal Plants at FRLHT is a facility
established for testing the medicinal plants and / or herbal
medicines as per the Ayurvedic Pharmacopoeia of India, the Indian
Herbal Pharmacopoeia, the Indian Pharmacopoeia, the British Herbal
Pharmacopoeia, the British Pharmacopoeia and the WHO guidelines for
quality control methods for medicinal plant materials. It is
intended to serve as a central facility for NGOs, small scale
manufacturers of herbal medicines, traders, academicians,
researchers, students and export organisations for quality testing
of raw drugs or compounded herbal medicines. Unlike pharmaceuticals
with a known molecular structure, the testing and standardisation
procedures of herbal medicines and formulations must be based on the
principles, concepts and categories of Indian Systems of Medicine.
This work of correlating in a sensitive and balanced way,
traditional knowledge with modern concepts and tools, is a huge and
unchartered field, that the lab group has chosen to traverse. The
Laboratory is also involved in understanding the contemporary
relevance of Traditional knowledge involved in collection and
processing of medicinal plants and interpretation of this knowledge
using modern methods and tools.
Infrastructure and Facility The laboratory has the
requisite manpower and infrastructure for testing herbal medicines
and to carry out research and development activities (R&D).
Experienced and well-qualified scientists in the disciplines of
Phytochemistry, Pharmaceutical Sciences and Microbiology are
available for carrying out analytical work as required under the
drug-testing mandate for ISM drugs. They are supported by field
botanists and experts within FRLHT in the morphological and
macroscopic identification of plants.
Phytochemical
Section The
laboratory is equipped with all the basic equipment for
physico-chemical analysis, chemical analysis, and assay of chemical
compounds by volumetric, gravimetric, spectrophotometric ,HPLC &
HPTLC methods of specific marker compounds. Thin layer
chromatography facilities for finger printing of the herbal medicine
or the marker compounds are available for confirming the identity
and authenticity of the medicine.
Microbiological Section A full-fledged microbiology
section exists for testing bacterial and fungal contamination of
herbal material with sterile testing facilities (Laminar flow hood).
Anti microbial tests and a time saving and economical bioassay
method using brine shrimps for evaluating biological activity of the
herbal medicines are carried out for a preliminary screening of
drugs.
Molecular Biology Section This is a recent project given by Ministry
for Environment and Forest, Govt. of India for genetic Diversity
studies of Medicinal Plants.The main purpose of this project is
utilizing the modern molecular biology teschiniques in
identification of medicinal plants. By using the molecular biology
techniques such as DNA isolation and PCCR etc, it is envisaged to
develop DNA Fingerprints of some important but controversial plants.
Further it is also proposed to develop DNA markers for authenticated
medicinal plant(s), which may help in confirming the identity of a
plant or a plant-derived product.
Key Services The Laboratory provides
various custom based services for the needy customers like NGO's,
Small-scale manufacturers, R&D organisations, Students
etc.,
Testing and standardisation of herbal
medicines Authenticity of the raw drugs based on the morphological
characters is done for botanical and species identity. The tests
conducted are to determine physico-chemical standards regarding
total ash, water and alcohol soluble extractives, foreign organic
matter, and moisture content. Chromatographic finger printing of the
herbal medicines for their general profile or marker compounds is
done by Thin Layer Chromatography. Chemical assay of the
constituents or marker compounds is carried out using the latest
analytical techniques of UV and visible spectrophotometeric methods
or HPLC for known chemical constituents. The laboratory undertakes
the standardisation of herbal medicines as per the specific
requirements of the customers/organisations or as per the
conventional pharmacopoeial standards for the quality, purity and
strength of the drugs.
The herbal medicines are tested for their
microbial contamination and limits for bacterial and fungal count.
Contract testing of the individual raw drugs either on seasonal or
annual basis and the herbal medicines in production of the
individual NGO/ organisations can be taken up on mutually acceptable
terms and conditions.
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schedule, conditions etc.
Authenticity -
botanical Physico-chemical parameters Chemical
assay a. Spectrophotometric b.
HPLC Chromatographic fingerprinting Microbiological
tests Bioassay
 Product
development
The Laboratory undertakes custom based
development of herbal medicinal product development on a pilot scale
for commercial exploitation by the customer. Supporting data on
standardisation, consistency, stability of the product and in-built
quality control at different phases of production including the
quality of inputs could be worked out as per customer requirement. A
Memorandum of Understanding (MoU) would be executed according to
mutually agreeable terms and conditions bearing in mind the
confidentiality of customer information as well as the Intellectual
Property Rights (IPR) on the product.
Database information Computerised database information on botanical
identity and pharmacopoeial standards of 300 medicinal plants and
pharmacological activities including clinical reports on 175 plant
species is available. Database information on Pharmacognosy or
pharmacology can be provided at a cost of Rs. 500/- each. Specific
needs for other medicinal plants for which Pharmacognosy/
pharmacological information is required can be made available on
request on terms and conditions mutually
acceptable.
Training The Laboratory can provide training to
individuals or organisations in the testing of herbal medicines as
per pharmacopoeial standards, in thin layer chromatography
techniques for finger printing of the raw drugs or marker compounds,
in assay of the chemical compounds by spectrophotmetric and HPLC
techniques, in evaluation of herbal medicines for microbiological
contamination (bacteria and fungi), as well as in Quality Control
and Standardisation of herbal medicine.
Consultancy The
Laboratory can provide consultancy and need based services
on: }
Formulation of
research projects }
Formulation of herbal
products }
Information on
quality control and standardisation }
Good Manufacturing
Practices for herbal medicines }
Pharmacognosy and
Pharmacology of medicinal plants }
Reports on the
clinical evaluation of individual raw drug |